SENTOR Trial: Sentinel LND in High-Grade Endometrial Cancer
SLNB is a viable option for the surgical staging of endometrial cancer, demonstrating high diagnostic accuracy and sensitivity with minimal false negatives.
LACE trial: Laparoscopy vs. Open for Endometrial Cancer
Among women with stage I endometrial cancer, TLH is equivalent to TAH in terms of disease-free survival, supporting the use of laparoscopic surgery.
GOG 33: Surgical Pathologic Spread Patterns of Endometrial Cancer
Surgical pathology effectively identifies prognostic factors and spread patterns in Stage I endometrial carcinoma, supporting individualized postoperative therapy based on pathologic findings.
Clinical Significance of Molecular Testing of Endometrial Cancer
Update on the molecular classification of endometrial cancer and its clinical significance.
GOG-LAP2: Laparoscopy Compared With Laparotomy for Endometrial Cancer Staging
Laparoscopic surgical staging for uterine cancer is feasible and safe, showing fewer complications and shorter hospital stays compared to laparotomy
GOG 261: Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Carcinosarcoma
Carboplatin/Taxol is not inferior to Ifos/Taxol in terms of OS and significantly increases PFS, making it a new standard treatment for carcinosarcoma
GOG 249: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer
The study did not demonstrate superiority or equivalence due to similar outcomes in both arms. The higher incidence of pelvic/para-aortic nodal failures in the VCB/C arm suggests the importance of pelvic RT in preventing regional recurrences.
KEYNOTE 775: Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer
Lenvatinib plus pembrolizumab significantly improves progression-free and overall survival compared to chemotherapy among patients with advanced endometrial cancer.
GOG 209: Carboplatin and Paclitaxel for Advanced Endometrial Cancer
The TC regimen demonstrated noninferiority to TAP in terms of OS and PFS while offering a better toxicity profile, making it a suitable first-line treatment for advanced endometrial cancer
GOG 258: Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer
Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer