LEAP-001: Pembro/Lenvima vs. Carbo/Taxol in Advanced/Recurrent Endometrial Cancer
First-line lenvatinib plus pembrolizumab did not significantly improve PFS or OS compared to chemotherapy in mismatch repair-proficient (pMMR) advanced endometrial cancer. Toxicity was higher in the experimental arm but manageable.
dMMR exploratory analysis shows promise in this subgroup.