Endometrial Cancer
GOG 122: Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma
AP chemotherapy significantly improved both progression-free and overall survival compared to WAI in patients with advanced endometrial carcinoma, although it was associated with greater acute toxicity.
PORTEC 1: EBRT vs. Observation in Endometrial Cancer
While postoperative radiotherapy reduces locoregional recurrence, it does not impact overall survival and increases treatment-related morbidity.
GOG-99 (Keys): Adjuvant Pelvic RT in Intermediate-Risk Endometrial Cancer
Surgical Considerations in Endometrial Cancer: Part 2
Surgical considerations in the management of stage 2 and advanced-stage endometrial cancer .
FIRES Trial: Sentinel LND in Endometrial Cancer
SENTOR Trial: Sentinel LND in High-Grade Endometrial Cancer
SLNB is a viable option for the surgical staging of endometrial cancer, demonstrating high diagnostic accuracy and sensitivity with minimal false negatives.
LACE trial: Laparoscopy vs. Open for Endometrial Cancer
Among women with stage I endometrial cancer, TLH is equivalent to TAH in terms of disease-free survival, supporting the use of laparoscopic surgery.
GOG 33: Surgical Pathologic Spread Patterns of Endometrial Cancer
Surgical pathology effectively identifies prognostic factors and spread patterns in Stage I endometrial carcinoma, supporting individualized postoperative therapy based on pathologic findings.
Clinical Significance of Molecular Testing of Endometrial Cancer
Update on the molecular classification of endometrial cancer and its clinical significance.