Clinical Significance of Molecular Testing of Endometrial Cancer

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Endometrial carcinoma: 10 years of TCGA (the cancer genome atlas): A critical reappraisal with comments on FIGO 2023 staging - PubMed
The Cancer Genome Atlas (TCGA) Research Network described 4 molecular subgroups of endometrial carcinomas with different outcome: 1) POLE ultramutated endometrioid carcinomas which have an indolent behavior; 2) microsatellite instability hypermutated endometrioid carcinomas associated with intermedi …

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Update in the molecular classification of endometrial carcinoma - PubMed
The pathological classification of endometrial carcinomas, one of the cornerstones in patient clinical management, has traditionally been based on morphologic features. However, this classification system does not fully reflect the biological diversity of endometrial carcinomas and has limited repro …
Molecular profile is a strong predictor of the pattern of recurrence in patients with endometrial cancer - PubMed
Endometrial cancer featured different patterns of recurrence depending on the molecular profile. p53-abnormal molecular profiling was the only independent risk factor for peritoneal relapse, while non-specific molecular profile showed a strong association with distant failures.
Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program - PubMed
The RAINBO program is registered at (NCT05255653).
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