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Study Summaries

GOG 252: Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma

The duration of PFS was not significantly increased with either IP regimen when combined with bevacizumab, and was better tolerated than IP cisplatin.

ICON8: Weekly Dose-Dense Chemotherapy in First-Line Epithelial Ovarian Cancer (Primary PFS Analysis)

Weekly dose-dense chemotherapy does not significantly improve progression-free survival compared to standard 3-weekly chemotherapy in a predominantly European population.

PRIMA: Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

Niraparib significantly extends progression-free survival among patients with newly diagnosed advanced ovarian cancer post-response to platinum-based chemotherapy, regardless of homologous-recombination deficiency status.

SHAPE: Simple vs. Radical Hysterectomy for Low-Risk Early-Stage Cervical Cancer

Simple hysterectomy is not inferior to radical hysterectomy in terms of the 3-year incidence of pelvic recurrence and presents a lower risk of urinary complications.

PAOLA-1: Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer

The addition of maintenance olaparib with bevacizumab significantly improves progression-free survival, especially in patients with HRD-positive tumors, including those without a BRCA mutation.

GOG 209: Carboplatin and Paclitaxel for Advanced Endometrial Cancer

The TC regimen demonstrated noninferiority to TAP in terms of OS and PFS while offering a better toxicity profile, making it a suitable first-line treatment for advanced endometrial cancer

KEYNOTE-826: Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer

Pembrolizumab significantly improves PFS and OS in PD-L1–positive persistent, recurrent, or metastatic cervical cancer patients when added to standard chemotherapy, with or without bevacizumab, maintaining a manageable safety profile.

Sarcoma Trials

List of key sarcoma trials

GOG 277: Adjuvant Gemcitabine Plus Docetaxel Followed by Doxorubicin Versus Observation for High-Grade Uterine Leiomyosarcoma

Adjuvant chemotherapy with gemcitabine plus docetaxel followed by doxorubicin does not show superior outcomes compared to observation for high-grade uterine leiomyosarcoma.

GeDDiS Trial: Gemcitabine and docetaxel versus doxorubicin as first-line treatment sarcomas

Doxorubicin remains the standard first-line treatment for most patients with advanced soft-tissue sarcoma, as gemcitabine and docetaxel did not demonstrate superiority in survival outcomes