ENGOT-EN5/GOG-3055/SIENDO: Selinexor in Endometrial Cancer (Phase II)
Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for
Shitanshu Uppal
Adjuvant Treatment of Endometrial Cancer - Part 2
Double-Barrelled Wet Colostomy
Video article demonstrating double barrelled wet colostomy formation in Pelvic Exenteration patients
GOG 3007: Megace Tamoxifen vs Letrozole Everolimus
Both treatment arms demonstrated clinically meaningful efficacy in patients with recurrent endometrial carcinoma. The combination of everolimus and letrozole showed a non-significant trend toward improved survival outcomes compared to standard hormonal therapy.
Publications Update # 57
Drug shortages, RUBY/GY018 decision aid, TOTEM trial and cancer statistics
TOTEM Trial: Intensive vs. Minimalist Follow-up in Endometrial Cancer
An intensive follow-up in patients treated for endometrial cancer does not improve overall survival or relapse detection significantly compared to a minimalist approach.
Adjuvant Treatment of Endometrial Cancer - Part 1
GOG 122: Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma
AP chemotherapy significantly improved both progression-free and overall survival compared to WAI in patients with advanced endometrial carcinoma, although it was associated with greater acute toxicity.
PORTEC 1: EBRT vs. Observation in Endometrial Cancer
While postoperative radiotherapy reduces locoregional recurrence, it does not impact overall survival and increases treatment-related morbidity.