Study Summaries
MITO 23
Trabectedin did not improve median OS and demonstrated a worse safety profile compared to physician’s choice chemotherapy.
FIRES Trial: Sentinel LND in Endometrial Cancer
SENTOR Trial: Sentinel LND in High-Grade Endometrial Cancer
SLNB is a viable option for the surgical staging of endometrial cancer, demonstrating high diagnostic accuracy and sensitivity with minimal false negatives.
LACE trial: Laparoscopy vs. Open for Endometrial Cancer
Among women with stage I endometrial cancer, TLH is equivalent to TAH in terms of disease-free survival, supporting the use of laparoscopic surgery.
GOG 33: Surgical Pathologic Spread Patterns of Endometrial Cancer
Surgical pathology effectively identifies prognostic factors and spread patterns in Stage I endometrial carcinoma, supporting individualized postoperative therapy based on pathologic findings.
Checkmate 0358: Nivolumab with or without ipilimumab in patients with recurrent or metastatic cervical cancer
Nivolumab alone or in combination with ipilimumab shows promise in recurrent or metastatic cervical cancer, with significant objective response rates and manageable safety profiles.
GOG-LAP2: Laparoscopy Compared With Laparotomy for Endometrial Cancer Staging
Laparoscopic surgical staging for uterine cancer is feasible and safe, showing fewer complications and shorter hospital stays compared to laparotomy
OV-HIPEC 1: Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer
The addition of HIPEC to interval cytoreductive surgery for stage III epithelial ovarian cancer significantly improves recurrence-free and overall survival without an increase in severe side effects.
GOG 279: Cisplatin, Gemcitabine, and IMRT for Locally Advanced Vulvar Carcinoma
Weekly Cisplatin and Gemcitabine concurrent with IMRT improved CPR in women with locally advanced vulvar squamous cell carcinoma not amenable to surgical resection.