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Study Summaries

Landoni Trial: Radical Surgery versus Radiotherapy for Stage Ib-IIa Cervical Cancer

There is no clear treatment of choice for early-stage cervical carcinoma in terms of overall or disease-free survival. Treatment should be tailored to individual patient factors such as menopausal status, age, medical conditions, histological type, and cervical diameter to achieve the best outcomes

CONCERV Trial

Conservative surgery is feasible for select patients with early-stage, low-risk cervical cancer

SENTIREC: SLND in Cervical Cancer Study from Denmark

SENTICOL 2: Quality of Life After Sentinel Lymph Node Dissection in Cervical Cancer

SENTICOL 1: Sentinel LND in Cervical Cancer

GOG 238: Radiation With or Without Cisplatin in Endometrial Cancer

Adding cisplatin to radiation therapy does not improve PFS or OS for patients with localized recurrences of endometrial cancer and results in higher toxicity rates. Radiation therapy alone remains an effective treatment for these patients.

ENGOT-EN5/GOG-3055/SIENDO: Selinexor in Endometrial Cancer (Phase II)

Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced

GOG 3007: Megace Tamoxifen vs Letrozole Everolimus

Both treatment arms demonstrated clinically meaningful efficacy in patients with recurrent endometrial carcinoma. The combination of everolimus and letrozole showed a non-significant trend toward improved survival outcomes compared to standard hormonal therapy.

TOTEM Trial: Intensive vs. Minimalist Follow-up in Endometrial Cancer

An intensive follow-up in patients treated for endometrial cancer does not improve overall survival or relapse detection significantly compared to a minimalist approach.

GOG 122: Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma

AP chemotherapy significantly improved both progression-free and overall survival compared to WAI in patients with advanced endometrial carcinoma, although it was associated with greater acute toxicity.