Study Summaries
GROINS V II: Radiotherapy Versus Inguinofemoral Lymphadenectomy
Inguinofemoral radiotherapy is a safe alternative for IFL in patients with SN micrometastases, showing minimal morbidity. However, for patients with SN macrometastasis, radiotherapy alone resulted in more isolated groin recurrences compared to IFL.
GOG 92: Sedlis Criteria Study
Adjuvant pelvic radiotherapy significantly reduces the risk of cancer recurrence in women with Stage IB cervical cancer who have undergone radical hysterectomy and pelvic lymphadenectomy and possess specific high-risk factors. The treatment is associated with higher but acceptable morbidity.
SIENDO Trial: Selinexor in TP53wt Advanced or Recurrent Endometrial Cancer
Landoni Trial: Radical Surgery versus Radiotherapy for Stage Ib-IIa Cervical Cancer
There is no clear treatment of choice for early-stage cervical carcinoma in terms of overall or disease-free survival. Treatment should be tailored to individual patient factors such as menopausal status, age, medical conditions, histological type, and cervical diameter to achieve the best outcomes
CONCERV Trial
Conservative surgery is feasible for select patients with early-stage, low-risk cervical cancer
SENTIREC: SLND in Cervical Cancer Study from Denmark
SENTICOL 2: Quality of Life After Sentinel Lymph Node Dissection in Cervical Cancer
SENTICOL 1: Sentinel LND in Cervical Cancer
GOG 238: Radiation With or Without Cisplatin in Endometrial Cancer
Adding cisplatin to radiation therapy does not improve PFS or OS for patients with localized recurrences of endometrial cancer and results in higher toxicity rates. Radiation therapy alone remains an effective treatment for these patients.