Study Summaries

TOTEM Trial: Intensive vs. Minimalist Follow-up in Endometrial Cancer

An intensive follow-up in patients treated for endometrial cancer does not improve overall survival or relapse detection significantly compared to a minimalist approach.

GOG 122: Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma

AP chemotherapy significantly improved both progression-free and overall survival compared to WAI in patients with advanced endometrial carcinoma, although it was associated with greater acute toxicity.

PORTEC 1: EBRT vs. Observation in Endometrial Cancer

While postoperative radiotherapy reduces locoregional recurrence, it does not impact overall survival and increases treatment-related morbidity.

GOG-99 (Keys): Adjuvant Pelvic RT in Intermediate-Risk Endometrial Cancer

MITO 23

Trabectedin did not improve median OS and demonstrated a worse safety profile compared to physician’s choice chemotherapy.

FIRES Trial: Sentinel LND in Endometrial Cancer

SENTOR Trial: Sentinel LND in High-Grade Endometrial Cancer

SLNB is a viable option for the surgical staging of endometrial cancer, demonstrating high diagnostic accuracy and sensitivity with minimal false negatives.

LACE trial: Laparoscopy vs. Open for Endometrial Cancer

Among women with stage I endometrial cancer, TLH is equivalent to TAH in terms of disease-free survival, supporting the use of laparoscopic surgery.

GOG 33: Surgical Pathologic Spread Patterns of Endometrial Cancer

Surgical pathology effectively identifies prognostic factors and spread patterns in Stage I endometrial carcinoma, supporting individualized postoperative therapy based on pathologic findings.

CheckMate 358: Nivolumab with or without Ipilimumab in Recurrent/Metastatic Cervical Cancer

Nivolumab alone or in combination with ipilimumab shows promise in recurrent or metastatic cervical cancer, with significant objective response rates and manageable safety profiles.