Publications Update # 28

Publications Update # 28
Photo by Lucas Ludwig / Unsplash Lake Superior Michigan

Non-Medical Article of the Week

In his incredibly vulnerable TED talk, Andy Dunn, the founder of Bonobos, an online clothing retailer, opens up about his diagnosis of bipolar type 1 disorder. Listening to him, I couldn't help but think about all the brilliant minds in our field and medicine as a whole who may be silently struggling with mental illness but are afraid to seek help due to the fear of regulatory burdens that could arise during medical license renewals or job searches. The last SGO practice survey showed that 40% of gyn oncologists had a positive screen for depression.

At a state level, as of 2021, according to this paper, most states continue to ask questions regarding physician mental health, and only eight states use recommended supportive language when inquiring about these issues.

Consistency Between State Medical License Applications and Recommendations Regarding Physician Mental Health - PubMed
This study examines the consistency of medical license applications with recommendations from the Federation of State Medical Boards on physician wellness and burnout.

My advice, if you need help, take it. Of course, remedies to fix the system, the workplace culture, etc., are long-term solutions. Still, as Andy Dunn mentioned in his talk, we must stop stigmatizing people and make mental health universally acceptable.

Cervical Cancer

Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994 - PubMed
This trial failed to demonstrate superiority in favor of the NACT-S arm but resulted in acceptable morbidity and HRQOL in both arms.

This is the second trial in recent years comparing the neoadjuvant chemotherapy for cervical cancer followed by a surgical resection. The rationale for these trials and the pursuit to identify an alternative to chemoradiotherapy is based on a simple reason: cervical cancer is highly prevalent in low and middle-income countries where access to radiotherapy and brachytherapy is often limited.

The first of these trials was published 2018 by Gupta et al. from the Tata Memorial Hospital in India.

Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial - PubMed
Purpose We compared the efficacy and toxicity of neoadjuvant chemotherapy followed by radical surgery versus standard cisplatin-based chemoradiation in patients with locally advanced squamous cervical cancer. Patients and Methods This was a single-center, phase III, randomized controlled trial ( Cli…

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