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Study Summaries

GOG 122: Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma

AP chemotherapy significantly improved both progression-free and overall survival compared to WAI in patients with advanced endometrial carcinoma, although it was associated with greater acute toxicity.

PORTEC 1: EBRT vs. Observation in Endometrial Cancer

While postoperative radiotherapy reduces locoregional recurrence, it does not impact overall survival and increases treatment-related morbidity.

GOG 99: Surgery With or Without EBRT in Intermediate Risk Endometrial Adenocarcinoma

MITO 23

Trabectedin did not improve median OS and demonstrated a worse safety profile compared to physician’s choice chemotherapy.

FIRES Trial: Sentinel LND in Endometrial Cancer

SENTOR Trial: Sentinel LND in High-Grade Endometrial Cancer

SLNB is a viable option for the surgical staging of endometrial cancer, demonstrating high diagnostic accuracy and sensitivity with minimal false negatives.

LACE trial: Laparoscopy vs. Open for Endometrial Cancer

Among women with stage I endometrial cancer, TLH is equivalent to TAH in terms of disease-free survival, supporting the use of laparoscopic surgery.

GOG 33: Surgical Pathologic Spread Patterns of Endometrial Cancer

Surgical pathology effectively identifies prognostic factors and spread patterns in Stage I endometrial carcinoma, supporting individualized postoperative therapy based on pathologic findings.

Checkmate 0358: Nivolumab with or without ipilimumab in patients with recurrent or metastatic cervical cancer

Nivolumab alone or in combination with ipilimumab shows promise in recurrent or metastatic cervical cancer, with significant objective response rates and manageable safety profiles.

GOG-LAP2: Laparoscopy Compared With Laparotomy for Endometrial Cancer Staging

Laparoscopic surgical staging for uterine cancer is feasible and safe, showing fewer complications and shorter hospital stays compared to laparotomy