Study Summaries

UTERUS-11: Surgical versus clinical staging before primary chemoradiation

GROINS V II: Radiotherapy Versus Inguinofemoral Lymphadenectomy

Inguinofemoral radiotherapy is a safe alternative for IFL in patients with SN micrometastases, showing minimal morbidity. However, for patients with SN macrometastasis, radiotherapy alone resulted in more isolated groin recurrences compared to IFL.

SIENDO Trial: Selinexor in TP53wt Advanced or Recurrent Endometrial Cancer

Landoni Trial: Radical Surgery versus Radiotherapy for Stage Ib-IIa Cervical Cancer

There is no clear treatment of choice for early-stage cervical carcinoma in terms of overall or disease-free survival. Treatment should be tailored to individual patient factors such as menopausal status, age, medical conditions, histological type, and cervical diameter to achieve the best outcomes

CONCERV Trial

Conservative surgery is feasible for select patients with early-stage, low-risk cervical cancer

SENTIREC: SLND in Cervical Cancer Study from Denmark

SENTICOL 2: Quality of Life After Sentinel Lymph Node Dissection in Cervical Cancer

SENTICOL 1: Sentinel LND in Cervical Cancer

GOG 238: Radiation With or Without Cisplatin in Endometrial Cancer

Adding cisplatin to radiation therapy does not improve PFS or OS for patients with localized recurrences of endometrial cancer and results in higher toxicity rates. Radiation therapy alone remains an effective treatment for these patients.

ENGOT-EN5/GOG-3055/SIENDO: Selinexor in Endometrial Cancer (Phase II)

Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced