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Shitanshu Uppal

PALEO Trial: Palbociclib + Letrozole in Endometrial Cancer

The combination of palbociclib and letrozole significantly improved PFS compared to placebo with letrozole. However, it was associated with higher hematologic toxicities, particularly neutropenia.

Fulvestrant + Abemaciclib

The combination of abemaciclib and fulvestrant shows promising efficacy and manageable toxicity in HR-positive advanced or recurrent endometrial cancer, especially in CN-L/NSMP tumors

GYOEDU Podcast

Spotify Link Website Link GYOEDU: Interview PodcastSeason 1GYOEDU PlusShitanshu Uppal

Publications Update # 83

A trick to powerful speaking, LEAP-001 Study: Pembro/Lenvima vs. Carbo/Taxol in EndoCa, Opportunistic Salpingectomy.

LEAP-001: Lenvatinib plus Pembrolizumab vs. Chemotherapy as First-Line Therapy for Advanced Endometrial Cancer

First-line lenvatinib plus pembrolizumab did not significantly improve PFS or OS compared to chemotherapy in mismatch repair-proficient (pMMR) advanced endometrial cancer. Toxicity was higher in the experimental arm but manageable. dMMR exploratory analysis shows promise in this subgroup.

Anticoagulation and Bleeding

Chemotherapy Infusion Emergencies

Publications Update # 82

Book recommendation - Get It Done by Ayelet Fishbach, MITO-18 trial summary and discussion points, NEJM paper - BALANCE trial, Trial flashback - road to carboplatin and taxol video (5 mins)

GYOEDU Resident: Non-Epithelial Tumors of the Ovary

Hi there, This video is a part of the GYOEDU

CHIPOR: Secondary Debulking and HIPEC in Platinum-Sensitive Recurrent Ovarian Cancer

HIPEC combined with cytoreductive surgery significantly improved overall survival and progression-free survival in recurrent ovarian cancer