Shitanshu Uppal
PD-1 vs. PD-L1
Oral Mucositis Management
Management of oral mucositis and the MASCC guidelines
Publications Update # 68
Mucositis management, ATtend Trial, HER-2 expression in cell-free DNA and an ode to Michael Frumovitz
ATtend Trial: Atezolizumab + chemotherapy for advanced or recurrent endometrial cancer
Atezolizumab with chemotherapy improved progression-free survival in advanced or recurrent endometrial carcinoma, especially in dMMR tumors, though overall survival hasn't shown significant benefit yet. In the pMMR population, no significant PFS or OS benefit was observed; OS benefit is minimal.
Secondary Debulking Mini-Tutorial
Low-Grade Serous Ovarian Carcinoma
Relevant Study Summaries
GOG 281: Trametinib in recurrent low-grade serous
MILO/ENGOT-ov11: Binimetinib in Recurrent Low-Grade Serous
In low-grade serous ovarian cancer, Binimetinib did not significantly improve PFS compared to standard of care chemotherapy.
Publications Update # 67
Human creativity and the need for connection, mini-tutorial on low-grade serous ovarian cancer, p53 on preoperative biopsy in endometrial cancer, final overall survival in SOC-1 trial
SOC-1
Surgery did not improve overall survival, but it showed a benefit in certain analyses. This supports the potential efficacy of secondary cytoreduction in specialized centers and for selected patients.