Does the addition of Niraparib maintenance improve PFS in women with advanced ovarian cancer?

Placebo PO daily

q28 day cycles x36 months or until disease progression

Niraparib 300mg/200mg PO daily

PFS

Stage III/IV endometrioid or high grade serous ovarian cancer

prior platinum based chemotherapy with CR or PR

Niraparib vs Placebo:

median PFS, HRD: 21.9 vs 10.4 months (SS)

median PFS, HRD/BRCAm: 22.1 vs 10.9 months (SS)

median PFS for HRD/BRCAwt: 19.6 vs 8.2 months (SS)

median PFS for HR proficient: 8.1 vs 5.4 months (SS)

median PFS: 13.8 vs 8.2 months (SS)

2yr OS: 84% vs 77% (not mature)

2yr OS, HRD: 91% vs 85% (not mature)

Grade >3 adverse events: 70.5% vs 18.9% (most common: anemia, thrombocytopenia, neutropenia)