Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial
April 22, 2000
Does addition of adjuvant pelvic RT improve survival in early stage endometrial cancer?
Pelvic EBRT (4600 cGy)
no vaginal brachytherapy
locoregional recurrence, OS
stage I, grade 1 with ≥50% myometrial invasion
grade 2 with any invasion
grade 3 with <50% invasion
RT (n=354) vs observation (n=361):
5 yr Locoregional recurrence: 4% vs 14% (SS)
5 yr OS: 81% vs 85% (NS)
Adverse events: 25% vs 6% (Most GI)
Adjuvant pelvic RT improves locoregional control without impact on OS in women with early stage endometrial cancer.