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PORTEC 1

Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial

Date of Publication:

April 22, 2000

Pubmed Link:
Hypothesis:

Does addition of adjuvant pelvic RT improve survival in early stage endometrial cancer?

Control Arm(s):

Observation

Experimental Arm(s):

Pelvic EBRT (4600 cGy)

no vaginal brachytherapy

Primary End Point:

locoregional recurrence, OS

Inclusion Criteria:

stage I, grade 1 with ≥50% myometrial invasion

grade 2 with any invasion

grade 3 with <50% invasion

Exclusion Criteria:
Results:

RT (n=354) vs observation (n=361):

5 yr Locoregional recurrence: 4% vs 14% (SS)

5 yr OS: 81% vs 85% (NS)

Adverse events: 25% vs 6% (Most GI)

Conclusions:

Adjuvant pelvic RT improves locoregional control without impact on OS in women with early stage endometrial cancer.

Reviewer:
Kevin McCool, OTF