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Mayo Critiera Retrospective

Low-risk corpus cancer: Is lymphadenectomy or radiotherapy necessary?

Date of Publication:

June 1, 2000

Pubmed Link:
https://pubmed.ncbi.nlm.nih.gov/10871473/
Hypothesis:

What intraoperative pathologic indicators predict a group of uterine cancers that would not require lymphadenectomy or adjuvant radiotherapy?

Control Arm(s):
Experimental Arm(s):

Comparisons:

Hysterectomy/BSO with vs without lymphadenectomy

Tumor size ≤2cm vs > 2cm

Primary End Point:

PFS and DSS

Inclusion Criteria:

1984-1993

grade 1/2 uterine cancer

myometrial invasion < 50%

Exclusion Criteria:

intraoperative evidence of macroscopic extrauterine spread

Results:

n=328

5 yr DSS: 97%

5yr PFS: 96%

0 patients with tumor ≤2cm had positive LN or died of disease

LVSI vs no LVSI 5yr DSS: 77% vs. 98% (SS)

Conclusions:

Patients with grade 1/2 endometrioid cancers, <50% myometrial invasion, and without evidence of macroscopic disease may be treated with hysterectomy only.

Reviewer:
Diana Pearre, OTF