A Randomized Trial of Lymphadenectomy in Patients With Advanced Ovarian Neoplasms
February 28, 2019
Does performing a lymphadenectomy during primary surgical debulking improve survival in women with advanced ovarian cancer and clinically negative LN?
No lymphadenectomy at time of primary surgical debulking
Systematic lymphadenectomy at time of primary surgical debulking
Resectable stage IIB-IV ovarian cancer
Clinically negative lymph nodes
Lymphadenectomy vs. No Lymphadenectomy:
median PFS: 25.5 vs. 25.5 months (NS)
median OS: 65.5 vs. 69.2 mos (NS)
Lymph cysts (symptomatic): 3.1% vs. 0% (SS)
Repeat laparotomy: 12.4% vs. 6.5% (SS)
Transfusion PRBC: 63.7% vs. 56% (SS)
60-day mortality: 3.1% vs. 0.9% (SS)
Systematic lymphadenectomy was not associated with improved OS in women with advanced ovarian cancer, and was associated with a higher incidence of postoperative complications, including death.