Does performing a lymphadenectomy during primary surgical debulking improve survival in women with advanced ovarian cancer and clinically negative LN?

No lymphadenectomy at time of primary surgical debulking

Systematic lymphadenectomy at time of primary surgical debulking

OS

Resectable stage IIB-IV ovarian cancer

Macroscopic resection  

Clinically negative lymph nodes

Lymphadenectomy vs. No Lymphadenectomy:

median PFS: 25.5 vs. 25.5 months (NS)

median OS: 65.5 vs. 69.2 mos (NS)

Lymph cysts (symptomatic): 3.1% vs. 0% (SS)

Repeat laparotomy: 12.4% vs. 6.5% (SS)

Transfusion PRBC: 63.7% vs. 56% (SS)

60-day mortality: 3.1% vs. 0.9% (SS)