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Landoni

Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer

Date of Publication:

August 23, 1997

Pubmed Link:
https://www.ncbi.nlm.nih.gov/pubmed/9284774
Hypothesis:

Does treatment with surgery or RT improve survival for women with early stage cervical cancer?

Control Arm(s):

class III radical hysterectomyadjuvant RT (5040cGy) if - >stage IIA, <3mm uninvolved cervical stroma, cut-through, LN mets

Experimental Arm(s):

EBRT 4700cGy + brachytherapy (point A dose 7600cGy)

Primary End Point:

OS

Inclusion Criteria:

newly diagnosed stage IB or IIAage 30-70 yrs

Exclusion Criteria:
Results:

surgery (n=170) vs RT (n=167):64% of surgery pts received adjuvant RTmedian f/u: 87 mos5yr PFS: 74% vs 74% (NS)5yr OS: 83% vs 83% (NS)5yrs OS adeno: 70% vs 59% (SS)grade 2/3 toxicity: 28% vs 12% (SS)

Conclusions:

There is no treatment of choice for early stage cervical cancer. The combination of surgery and RT carries the highest morbidity

Reviewer:
Olga T Filippova