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ICON1

International collaborative ovarian neoplasm trial 1: a randomized trial of adjuvant chemotherapy in women with early-stage ovarian cancer

Date of Publication:

January 15, 2003

Pubmed Link:
https://pubmed.ncbi.nlm.nih.gov/12529345/
Hypothesis:

Does the addition of 6 cycles of platinum-based chemotherapy after complete surgical resection improve survival in women with early stage epithelial ovarian cancer?

Control Arm(s):

TAH/BSO+/- omentectomy

Experimental Arm(s):

TAH/BSO+/- omentectomy6 cycles of post-operative chemo (carboplatin AUC 5 or cyclophosphamide 500mg/m2 plus doxorubicin 50mg/m2 plus cisplatin 50mg/m2 (CAP) or cisplatin 70mg/m2)

Primary End Point:

OS

Inclusion Criteria:

epithelial ovarian cancerall visible tumor removed during surgeryprovider uncertain if post-operative chemotherapy was needed

Exclusion Criteria:

advanced stage disease

Results:

surgery only (n=236) vs surgery/chemotherapy (n=241):93% stage I 87% received carboplatin alone85% completed all 6 cyclesmedian f/u: 51 mos5yr PFS: 62% vs 73% (SS)5ys OS: 70% vs 79% (SS)

Conclusions:

The addition of platinum-based post-operative chemotherapy improves survival in women with early stage epithelial ovarian cancer after complete resection

Reviewer:
Olga T Filippova