International collaborative ovarian neoplasm trial 1: a randomized trial of adjuvant chemotherapy in women with early-stage ovarian cancer
January 15, 2003
Does the addition of 6 cycles of platinum-based chemotherapy after complete surgical resection improve survival in women with early stage epithelial ovarian cancer?
TAH/BSO+/- omentectomy6 cycles of post-operative chemo (carboplatin AUC 5 or cyclophosphamide 500mg/m2 plus doxorubicin 50mg/m2 plus cisplatin 50mg/m2 (CAP) or cisplatin 70mg/m2)
epithelial ovarian cancerall visible tumor removed during surgeryprovider uncertain if post-operative chemotherapy was needed
advanced stage disease
surgery only (n=236) vs surgery/chemotherapy (n=241):93% stage I 87% received carboplatin alone85% completed all 6 cyclesmedian f/u: 51 mos5yr PFS: 62% vs 73% (SS)5ys OS: 70% vs 79% (SS)
The addition of platinum-based post-operative chemotherapy improves survival in women with early stage epithelial ovarian cancer after complete resection