Groin Dissection Versus Groin Radiation in Carcinoma of the Vulva: A Gynecologic Oncology Group Study
November 2, 1992
Is groin RT superior to groin dissection for women with stage I-III vulvar cancer?
radical vulvectomyinguino-femoral lymphadenectomythose with +LNs received post-operative RT 5000cGy
radical vulvectomyb/l groin RT 5000cGy
PFS
squamous cell vulvar cancerstage I (+LVSI or >5mm invasion) to III
suspicious LN on examdistant metastases
lymphadenectomy (n=25) vs RT (n=27):20% of pts in lymphadenectomy group had +LNrecurrence: 0% vs 18.5% (SS)PFS and OS significantly worse for the RT groupstudy closed prematurely after interim analysis
Groin RT is significantly inferior to groin dissection in women with stage I-III squamous cell vulvar cancer