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GOG 71

Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecologic Oncology Group

Date of Publication:

June 1, 2003

Pubmed Link:
https://pubmed.ncbi.nlm.nih.gov/12798694/
Hypothesis:

Does an adjuvant hysterectomy after RT improve survival for women with bulky stage IB cervical cancer?

Control Arm(s):

total RT - 8000cGy to point A (EBRT - 4000cGy, intracavitary - 4000cGy) and 5500cGy to point B

Experimental Arm(s):

total RT - 7500cGy to point A (EBRT - 4500cGy, intracavitary - 3000cGy) and 5500cGy to point Bextrafascial hysterectomy (no parametria removed), BSO+/- lymphadenectomy

Primary End Point:

OS

Inclusion Criteria:

bulky stage IB cervical cancer (≥4cm)squamous, adenosquamous, adenocarcinoma

Exclusion Criteria:

ureteral obstruction

Results:

RT only (n=124) vs RT/surgery (n=132):grade 3/4 adverse events: 10% vs 10%median f/u time: 9.6 yrsrecurrence: 46% vs 37% (NS)death: 44% vs 42% (NS)

Conclusions:

The addition of an adjuvant hysterectomy does not improve survival in women with bulky stage IB cervical cancer

Reviewer:
Olga T Filippova