GOG 258

Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer

Date of Publication:

June 13, 2019

Pubmed Link:

Is the addition of RT to chemotherapy superior to chemotherapy alone for women with advanced endometrial cancer?

Control Arm(s):

carboplatin AUC 6 + paclitaxel 175 mg/m2
q21 days for 6 cycles

Experimental Arm(s):

EBRT (4500cGy in 25 fractions at 180cGy per fraction) with cisplatin 50 mg/m2 days 1 and 29  
carboplatin AUC 5 or 6 + paclitaxel 175 mg/m2
q21 days for 4 cycles (with G-CSF)

Primary End Point:


Inclusion Criteria:

stage III or IVA endometrial carcinoma of any histologic subtype
stage I or II clear cell or serous endometrial carcinoma and positive peritoneal washings
LN optional

Exclusion Criteria:

Recurrent endometrial carcinoma
residual tumor >2cm


chemoRT vs chemo:
median f/u: 47 mos
5yr PFS: 59% vs 58% (NS)
No subgroup analysis demonstrated benefit from chemoradiotherapy
5yr vaginal cuff recurrence: 2% vs 7% (SS)
5yr pelvic or para-aortic recurrence: 11% vs 20% (SS)
5yr distance recurrence: 27% vs 21% (NS)
Grade 3+ adverse effects: 58% vs 63%


Combined chemoRT did not provide a PFS benefit over chemotherapy alone in patients with advanced endometrial carcinoma.

Courtney Griffiths, OTF