Preoperative Chemoradiation for Advanced Vulvar Cancer: A Phase II Study of the Gynecologic Oncology Group
November 1, 1998
Is pre-operative chemo/RT feasible in women with advanced vulvar cancer?
RT 4760cGy5FU 1000mg/m2/day day 1-4 of RTcisplatin 50mg/m2 day 1 of RT repeat q4wkssurgical resection with b/l inguino-femoral lymphadenectomy
Conversion to a less radical procedure
squamous cell vulvar carcinomaT3-4 tumors
7pts did not undergo surgery46.5% no visible tumor prior to surgery53.5% with visible disease, including 3% residual unresectable disease4% could not preserve urinary and/or GI continence
Pre-operative RT is feasible in advanced squamous vulvar cancer and may reduce the radically of surgical resection