Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer
September 2, 2010
Is neoadjuvant chemotherapy followed by interval debulking surgery non-inferior to primary debulking surgery in advanced stage ovarian cancer?
Primary debulking surgeryat least 6 cycles platinum based chemotherapy
3 cycles platinum based chemotherapyinterval debulking surgery (if response or stable)at least 3 additional cycles of platinum based chemotherapy
OS (non-inferiority design)
stage IIIC or IV epithelial ovarian cancer
contraindication to PDS or NACT
PDS (n=336) vs NACT/IDS (n=334):≤1cm residual disease: 41.6% vs 80.6%Grade 5 complications: 2.5% vs 0.7% (comparison not performed)median PFS: 12 vs 12 months (NS)median OS: 29 vs 30 months (NS)
NACT/IDS is not inferior to PDS for advanced stage ovarian cancer patient