Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomized study
December 13, 2008
Does lymphadenectomy improving survival in women with endometrial cancer clinically confined to the uterus?
hysterectomy, BSO, peritoneal washings & palpation of para-aortic nodes
suspicious nodes resected
Standard surgery plus systematic pelvic lymphadenectomy
Clinically stage I or II endometrial cancer
Lymphadenectomy vs. standard surgery:
median f/u: 37 mos
5yr OS: 80% vs. 81% (NS)
5yr PFS: 73% vs 79% (NS)
more lymphedema in experimental arm
Systematic lymphadenectomy does not improve OS for women with clinical stage I or II endometrial cancer.