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ASTEC

Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomized study

Date of Publication:

December 13, 2008

Pubmed Link:
https://pubmed.ncbi.nlm.nih.gov/19070889/
Hypothesis:

Does lymphadenectomy improving survival in women with endometrial cancer clinically confined to the uterus?

Control Arm(s):

hysterectomy, BSO, peritoneal washings & palpation of para-aortic nodes

suspicious nodes resected

Experimental Arm(s):

Standard surgery plus systematic pelvic lymphadenectomy

Primary End Point:

OS

Inclusion Criteria:

Clinically stage I or II endometrial cancer

Exclusion Criteria:
Results:

Lymphadenectomy vs. standard surgery:

median f/u: 37 mos

5yr OS: 80% vs. 81% (NS)

5yr PFS: 73% vs 79% (NS)

more lymphedema in experimental arm

Conclusions:

Systematic lymphadenectomy does not improve OS for women with clinical stage I or II endometrial cancer.

Reviewer:
Ross Harrison, OTF