Prospective Validation Study of a Predictive Score for Operability of Recurrent Ovarian Cancer: The Multicenter Intergroup Study DESKTOP II.
February 1, 2011
Can the AGO score predict CGR during secondary debulking surgery?
secondary debulking surgery
predictability of CGR rate by AGO score
1st or 2nd recurrence of epithelial ovary cancerany stage at original diagnosisAGO criteria - ECOG 0, CGR at PDS, ascites <500mL - positive if all 3 criteria met
recurrence in <6mos after completion of prior treatment
516 total recurrences - 261 met AGO criteria - 148 had surgery (129 1st recurrence)median PFS prior to enrollment: 25.3mosCGR rate - 75% (76% if 1st recurrence)33% had at least 1 complication11% needed re-operation1pt died within 60 days
The AGO score is a valid tool to help select women for secondary debulking surgery in whom CGR is likely.