GYOEDU

AGO DESKTOP OVAR 2

Prospective Validation Study of a Predictive Score for Operability of Recurrent Ovarian Cancer: The Multicenter Intergroup Study DESKTOP II.

Date of Publication:

February 1, 2011

Pubmed Link:

https://pubmed.ncbi.nlm.nih.gov/21270612/

Hypothesis:

Can the AGO score predict CGR during secondary debulking surgery?

Control Arm(s):

Experimental Arm(s):

secondary debulking surgery

Primary End Point:

predictability of CGR rate by AGO score

Inclusion Criteria:

1st or 2nd recurrence of epithelial ovary cancerany stage at original diagnosisAGO criteria - ECOG 0, CGR at PDS, ascites <500mL - positive if all 3 criteria met

Exclusion Criteria:

recurrence in <6mos after completion of prior treatment

Results:

516 total recurrences - 261 met AGO criteria - 148 had surgery (129 1st recurrence)median PFS prior to enrollment: 25.3mosCGR rate - 75% (76% if 1st recurrence)33% had at least 1 complication11% needed re-operation1pt died within 60 days

Conclusions:

The AGO score is a valid tool to help select women for secondary debulking surgery in whom CGR is likely.

Reviewer:

Olga T Filippova