Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: european organization for research and treatment of cancer-adjuvant chemotherapy in ovarian cancer trial
January 15, 2003
Does the addition of post-operative platinum-based chemotherapy improved OS for women with early stage epithelial ovarian cancer?
TAH/BSO, staging (recommended - omentectomy, washings, biopsies, LN sampling)
TAH/BSO, staging (recommended - omentectomy, washings, biopsies, LN sampling)at least 4 (but recommend 6) cycles of platinum-based chemotherapy (cisplain 75mg/m2, carboplatin 350mg/m2)
stage IA-B grade 2/3stage IC and IIAstage I-IIA clear cell
surgery only (n=224) vs surgery/chemotherapy (n=224):33% of patients in each arm had recommended staging median f/u: 5.5 yrs5yr PFS: 68% vs 76% (SS)5yr OS: 78% vs 85% (NS)survival benefit of added chemotherapy mainly in women who did not have recommended staging
OS was only improved by the addition of adjuvant chemotherapy in women with early stage ovarian cancer who did not undergo recommended staging. For the whole cohort, no OS benefit was seen, only a PFS benefit.